Causal Modeling

A new dimension to access content of this website

Left: state-free prediction of the measured causal map in held-out worms. An identity-indexed model with no connectome scores 0.278 (fixed split, ceiling 0.44) and 0.451 (cross-validation, ceiling 0.59), against 0.105 and 0.127 for a connectome-constrained model and about zero with shuffled neuron names. Right: on its own test maps the connectome-constrained model beats a shuffled connectome within 10 µm of the stimulated neuron (0.214 vs -0.005) but not beyond 15 µm (0.008 vs 0.009).

Predicting causal signal flow in the C. elegans brain

Predicting how stimulating one C. elegans neuron moves the others in unseen worms: neuron identity reaches 77% of the noise ceiling (r = 0.451); the wiring diagram helps only within ~10 µm.